Assay Detail
Binding
CHEMBL5140787
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to amyloid beta (1 to 42) (unknown origin) fibrils
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Near-Infrared Fluorescent Probes as Imaging and Theranostic Modalities for Amyloid-Beta and Tau Aggregates in Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 5.45 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL594574 | — | — | 1 | 6.96 |
| CHEMBL594555 | — | — | 1 | 6.92 |
| CHEMBL5193431 | — | — | 1 | 5.50 |
| CHEMBL5197068 | — | — | 1 | 5.42 |
| CHEMBL5182263 | — | — | 1 | 5.11 |
| CHEMBL5196550 | — | — | 1 | 4.94 |
| CHEMBL5177420 | — | — | 1 | 4.76 |
| CHEMBL5195545 | — | — | 1 | 4.01 |
| CHEMBL5175560 | — | — | 1 | - |
| CHEMBL5179677 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL594574 | — | Kd | = | 110.0 | nM | 6.96 |
| CHEMBL594555 | — | Kd | = | 120.0 | nM | 6.92 |
| CHEMBL5193431 | — | Kd | = | 3190.0 | nM | 5.50 |
| CHEMBL5197068 | — | Kd | = | 3780.0 | nM | 5.42 |
| CHEMBL5182263 | — | Kd | = | 7780.0 | nM | 5.11 |
| CHEMBL5196550 | — | Kd | = | 11400.0 | nM | 4.94 |
| CHEMBL5177420 | — | Kd | = | 17350.0 | nM | 4.76 |
| CHEMBL5195545 | — | Kd | = | 97900.0 | nM | 4.01 |
| CHEMBL5175560 | — | Kd | = | 246300.0 | nM | - |
| CHEMBL5179677 | — | Kd | = | 847500.0 | nM | - |