Assay Detail
Binding
CHEMBL5140790
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Binding affinity to amyloid beta (1 to 42) (unknown origin) monomer
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Near-Infrared Fluorescent Probes as Imaging and Theranostic Modalities for Amyloid-Beta and Tau Aggregates in Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 5.08 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5183307 | — | — | 1 | 7.34 |
| CHEMBL5193431 | — | — | 1 | 4.88 |
| CHEMBL5182263 | — | — | 1 | 4.75 |
| CHEMBL5195545 | — | — | 1 | 4.60 |
| CHEMBL5177420 | — | — | 1 | 4.50 |
| CHEMBL5196550 | — | — | 1 | 4.40 |
| CHEMBL5175560 | — | — | 1 | - |
| CHEMBL5179677 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5183307 | — | Kd | = | 45.8 | nM | 7.34 |
| CHEMBL5193431 | — | Kd | = | 13120.0 | nM | 4.88 |
| CHEMBL5182263 | — | Kd | = | 17640.0 | nM | 4.75 |
| CHEMBL5195545 | — | Kd | = | 25300.0 | nM | 4.60 |
| CHEMBL5177420 | — | Kd | = | 31690.0 | nM | 4.50 |
| CHEMBL5196550 | — | Kd | = | 40200.0 | nM | 4.40 |
| CHEMBL5175560 | — | Kd | = | 280800.0 | nM | - |
| CHEMBL5179677 | — | Kd | = | 1086000.0 | nM | - |