Assay Detail
Binding
CHEMBL5140807
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]IMPY from amyloid beta (1 to 42) (unknown origin) measured by competitive radioligand binding assay
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Near-Infrared Fluorescent Probes as Imaging and Theranostic Modalities for Amyloid-Beta and Tau Aggregates in Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 7.41 | 7.84 |
| Ki | 2 | 7.03 | 7.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5192359 | — | — | 1 | 7.86 |
| CHEMBL5199963 | — | — | 1 | 7.84 |
| CHEMBL5193352 | — | — | 1 | 6.97 |
| CHEMBL5170177 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5192359 | — | Ki | = | 13.7 | nM | 7.86 |
| CHEMBL5199963 | — | Kd | = | 14.5 | nM | 7.84 |
| CHEMBL5193352 | — | Kd | = | 106.0 | nM | 6.97 |
| CHEMBL5170177 | — | Ki | = | 652.0 | nM | 6.19 |