Assay Detail
Binding
CHEMBL5140924
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DHT from Androgen receptor expressed in human MDA-MB-453 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-453 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Therapeutic Strategies to Target the Androgen Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.26 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL233773 | — | — | 1 | 9.35 |
| CHEMBL3932464 | — | — | 1 | 8.77 |
| CHEMBL5186213 | — | — | 1 | 8.62 |
| CHEMBL229264 | — | — | 1 | 8.49 |
| CHEMBL5194764 | — | — | 1 | 8.10 |
| CHEMBL5189989 | — | — | 1 | 7.85 |
| CHEMBL362566 | — | — | 1 | 7.75 |
| CHEMBL5186356 | — | — | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL233773 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL3932464 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL5186213 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL229264 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL5194764 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL5189989 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL362566 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL5186356 | — | Ki | = | 73.0 | nM | 7.14 |