Assay Detail
Functional
CHEMBL5140935
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Antiproliferative activity against human LNCaP cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Therapeutic Strategies to Target the Androgen Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.71 | 7.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4870803 | — | — | 1 | 7.79 |
| CHEMBL1082407 | ENZALUTAMIDE | 4.0 | 1 | 7.44 |
| CHEMBL1916251 | — | — | 1 | 7.23 |
| CHEMBL1916412 | — | — | 1 | 6.84 |
| CHEMBL409 | BICALUTAMIDE | 4.0 | 1 | 6.80 |
| CHEMBL1099086 | — | — | 1 | 6.39 |
| CHEMBL3622589 | — | — | 1 | 6.25 |
| CHEMBL2397334 | — | — | 1 | 4.94 |
| CHEMBL3323483 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4870803 | — | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL1082407 | ENZALUTAMIDE | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1916251 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL1916412 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL409 | BICALUTAMIDE | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1099086 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3622589 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL2397334 | — | IC50 | = | 11570.0 | nM | 4.94 |
| CHEMBL3323483 | — | IC50 | < | 500.0 | nM | - |