Assay Detail
Binding
CHEMBL5140936
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Antagonist activity at Androgen receptor in human MDA-MB-453 cells measured by SEAP reporter gene assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-453 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Therapeutic Strategies to Target the Androgen Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.29 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3932464 | — | — | 1 | 7.80 |
| CHEMBL5186213 | — | — | 1 | 7.72 |
| CHEMBL5189989 | — | — | 1 | 7.50 |
| CHEMBL5186356 | — | — | 1 | 7.22 |
| CHEMBL5194764 | — | — | 1 | 7.04 |
| CHEMBL362566 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3932464 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5186213 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5189989 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5186356 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5194764 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL362566 | — | IC50 | = | 350.0 | nM | 6.46 |