Assay Detail
Binding
CHEMBL5140966
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Antagonist activity at Androgen receptor in human LNCaP cells assessed as inhibition of PSA expression
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Therapeutic Strategies to Target the Androgen Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.45 | 6.77 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3323483 | — | — | 1 | 6.77 |
| CHEMBL1623389 | — | — | 1 | 6.55 |
| CHEMBL2316547 | — | — | 1 | 6.28 |
| CHEMBL4848581 | — | — | 1 | 6.18 |
| CHEMBL3622589 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3323483 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1623389 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL2316547 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4848581 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL3622589 | — | Activity | = | 80.0 | % | - |