Assay Detail
Binding
CHEMBL5141097
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to SIRT5 (unknown origin) assessed as deglutarylase activity by measuring inhibition constant
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial (CHEMBL2163183) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Therapeutic Potential and Activity Modulation of the Protein Lysine Deacylase Sirtuin 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.15 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5199270 | — | — | 1 | 9.30 |
| CHEMBL4636862 | — | — | 1 | 8.22 |
| CHEMBL5209031 | — | — | 1 | 8.15 |
| CHEMBL5172115 | — | — | 1 | 7.66 |
| CHEMBL5188575 | — | — | 1 | 7.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5199270 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL4636862 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL5209031 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL5172115 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL5188575 | — | Ki | = | 37.0 | nM | 7.43 |