Assay Detail
Binding
CHEMBL5141609
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Inhibition of full length Nano-luc fused EPHB3 in human HEK-293T cells incubated for 2 hrs by cell based NanoBRET target engagement assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.05 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3321809 | — | — | 1 | 8.15 |
| CHEMBL5191665 | — | — | 1 | 8.15 |
| CHEMBL5203261 | — | — | 1 | 8.15 |
| CHEMBL5202826 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3321809 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5191665 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5203261 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5202826 | — | IC50 | = | 18.0 | nM | 7.75 |