Assay Detail
Binding
CHEMBL5142216
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human SMARCA2 (S1337 to Q1486 residues) expressed in bacterial expression system by bromoscan assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Probable global transcription activator SNF2L2 (CHEMBL2362979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 6.91 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5207330 | — | — | 1 | 7.80 |
| CHEMBL3752911 | — | — | 1 | 7.75 |
| CHEMBL5177096 | — | — | 1 | 7.15 |
| CHEMBL5183240 | — | — | 1 | 6.47 |
| CHEMBL5194650 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5207330 | — | Kd | = | 16.0 | nM | 7.80 |
| CHEMBL3752911 | — | Kd | = | 18.0 | nM | 7.75 |
| CHEMBL5177096 | — | Kd | = | 71.0 | nM | 7.15 |
| CHEMBL5183240 | — | Kd | = | 340.0 | nM | 6.47 |
| CHEMBL5194650 | — | Kd | = | 4400.0 | nM | 5.36 |