Assay Detail
Binding
CHEMBL5142219
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SMARAC2 isoform B (unknown origin) expressed in U2OS cells co-expressed in NLS-ZsGreen incubated for 1 hrs by cellular target engagement assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Probable global transcription activator SNF2L2 (CHEMBL2362979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.76 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5207330 | — | — | 1 | 7.00 |
| CHEMBL5177096 | — | — | 1 | 6.52 |
| CHEMBL5183240 | — | — | 1 | - |
| CHEMBL5194650 | — | — | 1 | - |
| CHEMBL3752911 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5207330 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5177096 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5183240 | — | EC50 | - | — | - | |
| CHEMBL5194650 | — | EC50 | - | — | - | |
| CHEMBL3752911 | — | EC50 | - | — | - |