Assay Detail
Binding
CHEMBL5142379
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrs
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Alpha-ketoglutarate-dependent dioxygenase FTO (CHEMBL2331065) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Rational Design and Optimization of m<sup>6</sup>A-RNA Demethylase FTO Inhibitors as Anticancer Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.02 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5195767 | — | — | 1 | 7.16 |
| CHEMBL5200892 | — | — | 1 | 6.96 |
| CHEMBL5207866 | — | — | 1 | 6.80 |
| CHEMBL5194680 | — | — | 1 | 6.57 |
| CHEMBL5204291 | — | — | 1 | 6.46 |
| CHEMBL5207797 | — | — | 1 | 6.46 |
| CHEMBL5203668 | — | — | 1 | 6.36 |
| CHEMBL5186890 | — | — | 1 | 6.17 |
| CHEMBL5181285 | — | — | 1 | 6.09 |
| CHEMBL5199622 | — | — | 1 | 6.08 |
| CHEMBL5177222 | — | — | 1 | 6.06 |
| CHEMBL5182180 | — | — | 1 | 6.05 |
| CHEMBL5191997 | — | — | 1 | 6.02 |
| CHEMBL5208073 | — | — | 1 | 6.00 |
| CHEMBL5174078 | — | — | 1 | 6.00 |
| CHEMBL5174480 | — | — | 1 | 5.96 |
| CHEMBL5184614 | — | — | 1 | 5.89 |
| CHEMBL5195274 | — | — | 1 | 5.89 |
| CHEMBL5205687 | — | — | 1 | 5.89 |
| CHEMBL5205984 | — | — | 1 | 5.82 |
| CHEMBL5188113 | — | — | 1 | 5.77 |
| CHEMBL5208226 | — | — | 1 | 5.70 |
| CHEMBL5208008 | — | — | 1 | 5.70 |
| CHEMBL5195210 | — | — | 1 | 5.68 |
| CHEMBL5198269 | — | — | 1 | 5.66 |
| CHEMBL5182267 | — | — | 1 | 5.60 |
| CHEMBL5169524 | — | — | 1 | 5.52 |
| CHEMBL5176984 | — | — | 1 | 5.47 |
| CHEMBL5197784 | — | — | 1 | 5.40 |
| CHEMBL5196700 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5195767 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5200892 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5207866 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5194680 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5204291 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5207797 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5203668 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5186890 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL5181285 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL5199622 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL5177222 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL5182180 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5191997 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL5208073 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5174078 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5174480 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5184614 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5195274 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5205687 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5205984 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5188113 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5208226 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5208008 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5195210 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5198269 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5182267 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5169524 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5176984 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5197784 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5196700 | — | IC50 | = | 4300.0 | nM | 5.37 |