Assay Detail
Functional
CHEMBL5142998
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Semisynthetic Transformations on (+)-Boldine Reveal a 5-HT<sub>2A/2C</sub>R Antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.72 | 5.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5204813 | — | — | 1 | 5.91 |
| CHEMBL5195241 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5204813 | — | IC50 | = | 1227.0 | nM | 5.91 |
| CHEMBL5195241 | — | IC50 | = | 3000.0 | nM | 5.52 |