Assay Detail
Binding
CHEMBL5143769
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin)
37
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Emerging Approaches to Overcome Acquired Drug Resistance Obstacles to Osimertinib in Non-Small-Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 7.69 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5169450 | — | — | 1 | 9.80 |
| CHEMBL5174418 | — | — | 1 | 9.59 |
| CHEMBL4443483 | — | — | 1 | 8.66 |
| CHEMBL5190204 | — | — | 1 | 8.40 |
| CHEMBL5180839 | — | — | 1 | 8.30 |
| CHEMBL4090686 | — | — | 1 | 8.15 |
| CHEMBL4061829 | — | — | 1 | 8.12 |
| CHEMBL4100860 | — | — | 1 | 8.10 |
| CHEMBL4799276 | — | — | 1 | 8.07 |
| CHEMBL4753389 | — | — | 1 | 8.07 |
| CHEMBL4649261 | — | — | 2 | 8.07 |
| CHEMBL4089892 | — | — | 1 | 8.05 |
| CHEMBL5205022 | — | — | 1 | 8.03 |
| CHEMBL4071368 | — | — | 1 | 7.96 |
| CHEMBL4558528 | — | — | 1 | 7.89 |
| CHEMBL4795878 | — | — | 1 | 7.75 |
| CHEMBL4533337 | — | — | 1 | 7.72 |
| CHEMBL5206817 | — | — | 1 | 7.72 |
| CHEMBL4101719 | — | — | 1 | 7.68 |
| CHEMBL4744973 | — | — | 1 | 7.66 |
| CHEMBL4530686 | — | — | 1 | 7.64 |
| CHEMBL5206600 | — | — | 1 | 7.56 |
| CHEMBL5194245 | — | — | 1 | 7.42 |
| CHEMBL4786787 | — | — | 1 | 7.40 |
| CHEMBL5183865 | — | — | 1 | 7.39 |
| CHEMBL5195167 | — | — | 1 | 7.32 |
| CHEMBL5200385 | — | — | 1 | 7.32 |
| CHEMBL5180830 | — | — | 1 | 7.28 |
| CHEMBL5195321 | — | — | 1 | 7.28 |
| CHEMBL4520903 | — | — | 1 | 7.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5169450 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL5174418 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL4443483 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL5190204 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5180839 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4090686 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4061829 | — | IC50 | = | 7.64 | nM | 8.12 |
| CHEMBL4100860 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4649261 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL4753389 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL4799276 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL4089892 | — | IC50 | = | 8.83 | nM | 8.05 |
| CHEMBL5205022 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL4071368 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4558528 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4795878 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4533337 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5206817 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4101719 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4744973 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4530686 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5206600 | — | IC50 | = | 27.5 | nM | 7.56 |
| CHEMBL5194245 | — | IC50 | = | 38.1 | nM | 7.42 |
| CHEMBL4786787 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5183865 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5195167 | — | IC50 | = | 48.2 | nM | 7.32 |
| CHEMBL5200385 | — | IC50 | = | 47.8 | nM | 7.32 |
| CHEMBL5195321 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5180830 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4520903 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4090601 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL4098072 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4228518 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL4649261 | — | IC50 | = | 218.3 | nM | 6.66 |
| CHEMBL5190294 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL24828 | VANDETANIB | IC50 | = | 369.2 | nM | 6.43 |
| CHEMBL4209019 | — | IC50 | = | 662.0 | nM | 6.18 |