Assay Detail
Binding
CHEMBL5143771
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Inhibition of EGFR Del19/T790M/C797S triple mutant (unknown origin)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Emerging Approaches to Overcome Acquired Drug Resistance Obstacles to Osimertinib in Non-Small-Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.16 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5172794 | — | — | 1 | 9.70 |
| CHEMBL5176129 | — | — | 1 | 9.70 |
| CHEMBL5174418 | — | — | 1 | 9.67 |
| CHEMBL5169450 | — | — | 1 | 9.66 |
| CHEMBL5187838 | — | — | 1 | 9.10 |
| CHEMBL5195167 | — | — | 1 | 7.92 |
| CHEMBL4649261 | — | — | 1 | 7.82 |
| CHEMBL4218431 | — | — | 1 | 7.75 |
| CHEMBL4207984 | — | — | 1 | 7.64 |
| CHEMBL4214588 | — | — | 1 | 7.34 |
| CHEMBL1328065 | — | — | 1 | 6.83 |
| CHEMBL5190294 | — | — | 1 | 6.51 |
| CHEMBL4443483 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5172794 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5176129 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5174418 | — | IC50 | = | 0.212 | nM | 9.67 |
| CHEMBL5169450 | — | IC50 | = | 0.218 | nM | 9.66 |
| CHEMBL5187838 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL5195167 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4649261 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL4218431 | — | IC50 | = | 17.9 | nM | 7.75 |
| CHEMBL4207984 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4214588 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL1328065 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL5190294 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4443483 | — | IC50 | = | 331.3 | nM | 6.48 |