Assay Detail
Binding
CHEMBL5144037
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Inhibition of SMYD2 (unknown origin) using 3H-SAM as substrate incubated for 1 hr by filter binding method
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Positioning of an unprecedented 1,5-oxaza spiroquinone scaffold into SMYD2 inhibitors in epigenetic space.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 5.89 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3819011 | — | — | 1 | 8.52 |
| CHEMBL3818083 | — | — | 1 | 7.57 |
| CHEMBL2169920 | — | — | 1 | 6.92 |
| CHEMBL5188628 | — | — | 1 | 6.40 |
| CHEMBL3414623 | — | — | 1 | 6.37 |
| CHEMBL5172262 | — | — | 1 | 6.17 |
| CHEMBL5170181 | — | — | 1 | 6.17 |
| CHEMBL5184091 | — | — | 1 | 5.67 |
| CHEMBL5207034 | — | — | 1 | 5.64 |
| CHEMBL5190397 | — | — | 1 | 5.62 |
| CHEMBL5191647 | — | — | 1 | 5.51 |
| CHEMBL5181874 | — | — | 1 | 5.51 |
| CHEMBL5198917 | — | — | 1 | 5.42 |
| CHEMBL5199015 | — | — | 1 | 5.26 |
| CHEMBL5180712 | — | — | 1 | 5.24 |
| CHEMBL5200671 | — | — | 1 | 5.21 |
| CHEMBL5176478 | — | — | 1 | 5.12 |
| CHEMBL5175819 | — | — | 1 | 4.94 |
| CHEMBL4476753 | — | — | 1 | 4.73 |
| CHEMBL5196609 | — | — | 1 | - |
| CHEMBL5202235 | — | — | 1 | - |
| CHEMBL5204697 | — | — | 1 | - |
| CHEMBL5190577 | — | — | 1 | - |
| CHEMBL5182950 | — | — | 1 | - |
| CHEMBL5200846 | — | — | 1 | - |
| CHEMBL5193070 | — | — | 1 | - |
| CHEMBL5189265 | — | — | 1 | - |
| CHEMBL5196302 | — | — | 1 | - |
| CHEMBL5187033 | — | — | 1 | - |
| CHEMBL5194340 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3819011 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3818083 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2169920 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5188628 | — | IC50 | = | 399.0 | nM | 6.40 |
| CHEMBL3414623 | — | IC50 | = | 425.0 | nM | 6.37 |
| CHEMBL5172262 | — | IC50 | = | 679.0 | nM | 6.17 |
| CHEMBL5170181 | — | IC50 | = | 678.0 | nM | 6.17 |
| CHEMBL5184091 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL5207034 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL5190397 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL5191647 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL5181874 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL5198917 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL5199015 | — | IC50 | = | 5550.0 | nM | 5.26 |
| CHEMBL5180712 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL5200671 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5176478 | — | IC50 | = | 7520.0 | nM | 5.12 |
| CHEMBL5175819 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL4476753 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL5187033 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5194131 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5206631 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5184109 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5206649 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5207271 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5189975 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5191667 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5194340 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5196609 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5196302 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5189265 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5193070 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5200846 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5182950 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5190577 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5204697 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5202235 | — | IC50 | > | 30000.0 | nM | - |