Assay Detail
Binding
CHEMBL5144097
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to full length FLAG/HA/Strep-tagged TLK2 (388 to 772 residues) (unknown origin) transfected in HEK293T cells by Alexa Fluor 647 staining based FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase tousled-like 2 (CHEMBL5404) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of bisindole derivatives as anticancer agents against Tousled-like kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.33 | 7.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5204542 | — | — | 1 | 7.73 |
| CHEMBL5188455 | — | — | 1 | 7.48 |
| CHEMBL5173181 | — | — | 1 | 6.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5204542 | — | IC50 | = | 18.65 | nM | 7.73 |
| CHEMBL5188455 | — | IC50 | = | 33.15 | nM | 7.48 |
| CHEMBL5173181 | — | IC50 | = | 163.4 | nM | 6.79 |