Assay Detail
Functional
CHEMBL5144112
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Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of bisindole derivatives as anticancer agents against Tousled-like kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.22 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5204542 | — | — | 1 | 6.43 |
| CHEMBL5188455 | — | — | 1 | 6.41 |
| CHEMBL5181676 | — | — | 1 | 6.22 |
| CHEMBL5205943 | — | — | 1 | 6.15 |
| CHEMBL5173181 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5204542 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5188455 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5181676 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5205943 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL5173181 | — | IC50 | = | 1280.0 | nM | 5.89 |