Assay Detail
Binding
CHEMBL5144411
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SE in Candida albicans ATCC SC5314 incubated for 30 mins using squalene as substrate in presence of NADPH by spectrophotometer analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Candida albicans |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Construction and activity evaluation of novel benzodioxane derivatives as dual-target antifungal inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.26 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL626 | NAFTIFINE | 4.0 | 1 | 6.50 |
| CHEMBL5206822 | — | — | 1 | 6.21 |
| CHEMBL5180750 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL626 | NAFTIFINE | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL5206822 | — | IC50 | = | 621.0 | nM | 6.21 |
| CHEMBL5180750 | — | IC50 | = | 823.0 | nM | 6.08 |