Assay Detail
Binding
CHEMBL5144623
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Inhibition of human SGLT2 expressed in CHO cells by methyl-alpha-D-glucopyranoside assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of GCC5694A: A potent and selective sodium glucose co-transporter 2 inhibitor for the treatment of type 2 diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 8.94 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3703920 | — | — | 1 | 9.43 |
| CHEMBL3703785 | — | — | 1 | 9.36 |
| CHEMBL3703921 | ENAVOGLIFLOZIN | 3.0 | 1 | 9.34 |
| CHEMBL429910 | DAPAGLIFLOZIN | 4.0 | 1 | 9.31 |
| CHEMBL3703789 | — | — | 1 | 9.17 |
| CHEMBL3703800 | — | — | 1 | 9.14 |
| CHEMBL3703791 | — | — | 1 | 9.10 |
| CHEMBL3703930 | — | — | 1 | 9.10 |
| CHEMBL3703797 | — | — | 1 | 9.01 |
| CHEMBL3654929 | — | — | 1 | 8.94 |
| CHEMBL3703936 | — | — | 1 | 8.93 |
| CHEMBL3654892 | — | — | 1 | 8.91 |
| CHEMBL5208827 | — | — | 1 | 8.84 |
| CHEMBL3703804 | — | — | 1 | 8.82 |
| CHEMBL3703799 | — | — | 1 | 8.81 |
| CHEMBL3703801 | — | — | 1 | 8.76 |
| CHEMBL3703790 | — | — | 1 | 8.69 |
| CHEMBL3703906 | — | — | 1 | 8.68 |
| CHEMBL3703916 | — | — | 1 | 8.38 |
| CHEMBL5205876 | — | — | 1 | 8.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3703920 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL3703785 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL3703921 | ENAVOGLIFLOZIN | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL429910 | DAPAGLIFLOZIN | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL3703789 | — | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL3703800 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL3703791 | — | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL3703930 | — | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL3703797 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL3654929 | — | IC50 | = | 1.16 | nM | 8.94 |
| CHEMBL3703936 | — | IC50 | = | 1.17 | nM | 8.93 |
| CHEMBL3654892 | — | IC50 | = | 1.22 | nM | 8.91 |
| CHEMBL5208827 | — | IC50 | = | 1.44 | nM | 8.84 |
| CHEMBL3703804 | — | IC50 | = | 1.52 | nM | 8.82 |
| CHEMBL3703799 | — | IC50 | = | 1.53 | nM | 8.81 |
| CHEMBL3703801 | — | IC50 | = | 1.72 | nM | 8.76 |
| CHEMBL3703790 | — | IC50 | = | 2.03 | nM | 8.69 |
| CHEMBL3703906 | — | IC50 | = | 2.09 | nM | 8.68 |
| CHEMBL3703916 | — | IC50 | = | 4.22 | nM | 8.38 |
| CHEMBL5205876 | — | IC50 | = | 7.44 | nM | 8.13 |