Compound Detail
CHEMBL3703921
ENAVOGLIFLOZIN 🧪 Phase III
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🧪 Phase III
OC[C@H]1O[C@@H](c2cc(Cc3ccc(C4CC4)cc3)c(Cl)c3c2CCO3)[C@H](O)[C@@H](O)[C@@H]1O
Basic Information
| ChEMBL ID | CHEMBL3703921 |
| Name | ENAVOGLIFLOZIN |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | KORCWPOBTZTAFI-YVTYUBGGSA-N |
2
Targets
4
Activities
1
Assay Types
9
PK Parameters
6
Publications
5
Known Names
2
Indications
Molecular Properties
446.9
MW (Da)
2.26
ALogP
6
HBA
4
HBD
99.4
PSA (Ų)
0.56
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Indications
Diabetes Mellitus Diabetes Mellitus, Type 2
ATC Classification
A10BK09
enavogliflozin
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: DRUGS USED IN DIABETES
Activity Summary
IC50 4 meas. best 9.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium/glucose cotransporter 2 CHEMBL3884 | IC50 | 9.34 | 9.3333 | 0.5 | 3 |
| Sodium/glucose cotransporter 1 CHEMBL4979 | IC50 | 6.45 | 6.45 | 359.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 4175.9 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 16160.3 | ng.hr.mL-1 | Rattus norvegicus |
| Cmax | 7390.42 | nM | Rattus norvegicus |
| Cmax | 5242.43 | nM | Rattus norvegicus |
| F | 77.4 | % | Rattus norvegicus |
| T1/2 | 4.6 | hr | Rattus norvegicus |
| T1/2 | 4.9 | hr | Rattus norvegicus |
| Tmax | 0.08 | hr | Rattus norvegicus |
| Tmax | 0.25 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium/glucose cotransporter 2 | IC50 | = | 0.46 | nM | 9.34 | Inhibition of human SGLT2 expressed in CHO cells by methyl-alpha-D-glucopyranosi... | 34813882 |
| Sodium/glucose cotransporter 2 | IC50 | = | 0.463 | nM | 9.33 | Inhibition Assay: For sodium-dependent glucose transport assay, cells expressing... | - |
| Sodium/glucose cotransporter 2 | IC50 | = | 0.463 | nM | 9.33 | Inhibition Assay: For sodium-dependent glucose transport assay, cells expressing... | - |
| Sodium/glucose cotransporter 1 | IC50 | = | 359.0 | nM | 6.45 | Inhibition of human SGLT1 expressed in CHO cells by methyl-alpha-D-glucopyranosi... | 34813882 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34813882 | 10.1016/j.bmcl.2021.128466 | ADMET | 10 |
| 34813882 | 10.1016/j.bmcl.2021.128466 | Rattus norvegicus | 3 |
| 34813882 | 10.1016/j.bmcl.2021.128466 | Mus musculus | 2 |
| 34813882 | 10.1016/j.bmcl.2021.128466 | Sodium/glucose cotransporter 2 | 1 |
| 34813882 | 10.1016/j.bmcl.2021.128466 | Sodium/glucose cotransporter 1 | 1 |
| 34813882 | 10.1016/j.bmcl.2021.128466 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine