Assay Detail
Binding
CHEMBL5144624
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Inhibition of human SGLT1 expressed in CHO cells by methyl-alpha-D-glucopyranoside assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of GCC5694A: A potent and selective sodium glucose co-transporter 2 inhibitor for the treatment of type 2 diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.47 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3703785 | — | — | 1 | 7.82 |
| CHEMBL3703797 | — | — | 1 | 7.77 |
| CHEMBL3703801 | — | — | 1 | 7.46 |
| CHEMBL3703789 | — | — | 1 | 7.43 |
| CHEMBL3703906 | — | — | 1 | 7.11 |
| CHEMBL3703920 | — | — | 1 | 6.79 |
| CHEMBL3703921 | ENAVOGLIFLOZIN | 3.0 | 1 | 6.45 |
| CHEMBL3703799 | — | — | 1 | 6.40 |
| CHEMBL3703800 | — | — | 1 | 6.25 |
| CHEMBL3703936 | — | — | 1 | 5.86 |
| CHEMBL3703804 | — | — | 1 | 5.67 |
| CHEMBL3703930 | — | — | 1 | 5.31 |
| CHEMBL3654892 | — | — | 1 | 5.20 |
| CHEMBL3654929 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3703785 | — | IC50 | = | 15.2 | nM | 7.82 |
| CHEMBL3703797 | — | IC50 | = | 16.9 | nM | 7.77 |
| CHEMBL3703801 | — | IC50 | = | 34.4 | nM | 7.46 |
| CHEMBL3703789 | — | IC50 | = | 37.2 | nM | 7.43 |
| CHEMBL3703906 | — | IC50 | = | 78.1 | nM | 7.11 |
| CHEMBL3703920 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL3703921 | ENAVOGLIFLOZIN | IC50 | = | 359.0 | nM | 6.45 |
| CHEMBL3703799 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3703800 | — | IC50 | = | 556.0 | nM | 6.25 |
| CHEMBL3703936 | — | IC50 | = | 1368.0 | nM | 5.86 |
| CHEMBL3703804 | — | IC50 | = | 2141.0 | nM | 5.67 |
| CHEMBL3703930 | — | IC50 | = | 4940.0 | nM | 5.31 |
| CHEMBL3654892 | — | IC50 | = | 6283.0 | nM | 5.20 |
| CHEMBL3654929 | — | IC50 | = | 9931.0 | nM | 5.00 |