Assay Detail
Functional
CHEMBL5144718
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Antiproliferative activity against human A-431 cells measured after 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Quinazoline-based hydroxamic acid derivatives as dual histone methylation and deacetylation inhibitors for potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.32 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.20 |
| CHEMBL5191361 | — | — | 1 | 5.62 |
| CHEMBL2441082 | — | — | 1 | 5.47 |
| CHEMBL5182385 | — | — | 1 | 5.23 |
| CHEMBL5201140 | — | — | 1 | 4.77 |
| CHEMBL5204152 | — | — | 1 | 4.64 |
| CHEMBL5187697 | — | — | 1 | - |
| CHEMBL5171881 | — | — | 1 | - |
| CHEMBL5171820 | — | — | 1 | - |
| CHEMBL5206158 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL5191361 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL2441082 | — | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL5182385 | — | IC50 | = | 5860.0 | nM | 5.23 |
| CHEMBL5201140 | — | IC50 | = | 16930.0 | nM | 4.77 |
| CHEMBL5204152 | — | IC50 | = | 23130.0 | nM | 4.64 |
| CHEMBL5187697 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5171881 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5171820 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5206158 | — | IC50 | > | 50000.0 | nM | - |