Assay Detail
Functional
CHEMBL5144832
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Antiviral activity against HIV1 with RT E138K mutant infected in human MT4 cells cells assessed as protection against viral-induced cytopathogenecity by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Indolylarylsulfones bearing phenylboronic acid and phenylboronate ester functionalities as potent HIV‑1 non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 7.05 | 8.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.18 |
| CHEMBL85059 | — | — | 1 | 8.00 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 7.72 |
| CHEMBL5169495 | — | — | 1 | 7.47 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.46 |
| CHEMBL5171267 | — | — | 1 | 7.40 |
| CHEMBL5174976 | — | — | 1 | 7.35 |
| CHEMBL5177915 | — | — | 1 | 7.30 |
| CHEMBL5208494 | — | — | 1 | 7.27 |
| CHEMBL5192642 | — | — | 1 | 7.19 |
| CHEMBL5197516 | — | — | 1 | 7.17 |
| CHEMBL5171768 | — | — | 1 | 7.07 |
| CHEMBL5193534 | — | — | 1 | 6.79 |
| CHEMBL5183571 | — | — | 1 | 6.61 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.56 |
| CHEMBL5173828 | — | — | 1 | 6.19 |
| CHEMBL5206637 | — | — | 1 | 6.14 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 6.6 | nM | 8.18 |
| CHEMBL85059 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5169495 | — | EC50 | = | 34.2 | nM | 7.47 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 34.7 | nM | 7.46 |
| CHEMBL5171267 | — | EC50 | = | 39.8 | nM | 7.40 |
| CHEMBL5174976 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5177915 | — | EC50 | = | 50.3 | nM | 7.30 |
| CHEMBL5208494 | — | EC50 | = | 53.7 | nM | 7.27 |
| CHEMBL5192642 | — | EC50 | = | 64.9 | nM | 7.19 |
| CHEMBL5197516 | — | EC50 | = | 67.6 | nM | 7.17 |
| CHEMBL5171768 | — | EC50 | = | 84.4 | nM | 7.07 |
| CHEMBL5193534 | — | EC50 | = | 162.2 | nM | 6.79 |
| CHEMBL5183571 | — | EC50 | = | 243.0 | nM | 6.61 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 277.2 | nM | 6.56 |
| CHEMBL5173828 | — | EC50 | = | 645.9 | nM | 6.19 |
| CHEMBL5206637 | — | EC50 | = | 716.9 | nM | 6.14 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 8266.1 | nM | 5.08 |