Assay Detail
Functional
CHEMBL5144863
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Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in TNFalpha protein expression level after 24 hrs by ELISA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.98 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.68 |
| CHEMBL5197941 | — | — | 1 | 5.40 |
| CHEMBL5176925 | — | — | 1 | 4.82 |
| CHEMBL3633777 | — | — | 1 | 4.73 |
| CHEMBL5202664 | — | — | 1 | 4.68 |
| CHEMBL5202128 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521 | IBUPROFEN | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5197941 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5176925 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL3633777 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL5202664 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL5202128 | — | IC50 | = | 28400.0 | nM | 4.55 |