Assay Detail
Functional
CHEMBL5144865
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Antitubercular activity against Mycobacterium tuberculosis M299 assessed as reduction in microbial growth after 5 days by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mycobacterium tuberculosis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.06 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374478 | RIFAMPIN | 4.0 | 1 | 5.92 |
| CHEMBL3633777 | — | — | 1 | 5.16 |
| CHEMBL5197941 | — | — | 1 | 5.11 |
| CHEMBL5202664 | — | — | 1 | 4.95 |
| CHEMBL5176925 | — | — | 1 | 4.61 |
| CHEMBL5202128 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374478 | RIFAMPIN | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3633777 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL5197941 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL5202664 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL5176925 | — | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL5202128 | — | IC50 | = | 24700.0 | nM | 4.61 |