Assay Detail
Binding
CHEMBL5145100
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Inhibition of SARS-CoV-2 RdRp
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Discovery of highly potent SARS-CoV-2 M<sup>pro</sup> inhibitors based on benzoisothiazolone scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.04 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1703831 | — | — | 1 | 5.19 |
| CHEMBL5176190 | — | — | 1 | 5.10 |
| CHEMBL5190812 | — | — | 1 | 4.82 |
| CHEMBL5198897 | — | — | 1 | - |
| CHEMBL5200414 | — | — | 1 | - |
| CHEMBL5191265 | — | — | 1 | - |
| CHEMBL5173090 | — | — | 1 | - |
| CHEMBL5198660 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1703831 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL5176190 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL5190812 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL5198897 | — | IC50 | - | — | - | |
| CHEMBL5200414 | — | IC50 | - | — | - | |
| CHEMBL5191265 | — | IC50 | - | — | - | |
| CHEMBL5173090 | — | IC50 | - | — | - | |
| CHEMBL5198660 | — | IC50 | - | — | - |