Assay Detail
Binding
CHEMBL5145471
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Inhibition of rat serum Butyrylcholine esterase using butyrylthiocholine as substrate incubated for 15 mins by DTNB reagent based Ellman's method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Serum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of naringenin-O-carbamate derivatives as multi-target-directed liagnds for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.70 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL636 | RIVASTIGMINE | 4.0 | 1 | 5.51 |
| CHEMBL4787451 | — | — | 1 | 4.84 |
| CHEMBL4762069 | — | — | 1 | 4.81 |
| CHEMBL5191631 | — | — | 1 | 4.77 |
| CHEMBL5200469 | — | — | 1 | 4.74 |
| CHEMBL4789142 | — | — | 1 | 4.71 |
| CHEMBL5186955 | — | — | 1 | 4.70 |
| CHEMBL5203673 | — | — | 1 | 4.70 |
| CHEMBL5205300 | — | — | 1 | 4.65 |
| CHEMBL5206469 | — | — | 1 | 4.63 |
| CHEMBL5200353 | — | — | 1 | 4.60 |
| CHEMBL4850938 | — | — | 1 | 4.58 |
| CHEMBL5208325 | — | — | 1 | 4.57 |
| CHEMBL5178833 | — | — | 1 | 4.57 |
| CHEMBL4852914 | — | — | 1 | 4.55 |
| CHEMBL5172518 | — | — | 1 | 4.53 |
| CHEMBL5172348 | — | — | 1 | 4.51 |
| CHEMBL32571 | — | — | 1 | - |
| CHEMBL28 | APIGENIN | — | 1 | - |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL636 | RIVASTIGMINE | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4787451 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL4762069 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL5191631 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL5200469 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL4789142 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL5186955 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL5203673 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL5205300 | — | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL5206469 | — | IC50 | = | 23600.0 | nM | 4.63 |
| CHEMBL5200353 | — | IC50 | = | 25200.0 | nM | 4.60 |
| CHEMBL4850938 | — | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL5208325 | — | IC50 | = | 27100.0 | nM | 4.57 |
| CHEMBL5178833 | — | IC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL4852914 | — | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL5172518 | — | IC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL5172348 | — | IC50 | = | 30600.0 | nM | 4.51 |
| CHEMBL32571 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL28 | APIGENIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL44 | GENISTEIN | IC50 | > | 50000.0 | nM | - |