Assay Detail
Binding
CHEMBL5146018
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Inhibition of JNK1 (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Unraveling the Design and Discovery of c-Jun N-Terminal Kinase Inhibitors and Their Therapeutic Potential in Human Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.68 | 8.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3393607 | — | — | 1 | 8.81 |
| CHEMBL2216824 | — | — | 1 | 8.33 |
| CHEMBL7064 | — | — | 1 | 7.40 |
| CHEMBL1288160 | — | — | 1 | 7.32 |
| CHEMBL3393606 | — | — | 1 | 6.09 |
| CHEMBL5200902 | — | — | 1 | 5.47 |
| CHEMBL3393605 | — | — | 1 | 5.11 |
| CHEMBL5172062 | — | — | 1 | 4.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3393607 | — | IC50 | = | 1.54 | nM | 8.81 |
| CHEMBL2216824 | — | IC50 | = | 4.67 | nM | 8.33 |
| CHEMBL7064 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1288160 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3393606 | — | IC50 | = | 809.0 | nM | 6.09 |
| CHEMBL5200902 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL3393605 | — | IC50 | = | 7780.0 | nM | 5.11 |
| CHEMBL5172062 | — | IC50 | = | 12200.0 | nM | 4.91 |