Compound Detail
CHEMBL5200902
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Basic Information
| ChEMBL ID | CHEMBL5200902 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GMWRFIUJXJEXQK-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
334.2
MW (Da)
1.40
ALogP
9
HBA
7
HBD
171.8
PSA (Ų)
0.32
QED
1
Ro5 Violations
1
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 8 CHEMBL2276 | IC50 | 5.47 | 5.47 | 3400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 8 | IC50 | = | 3400.0 | nM | 5.47 | Inhibition of JNK1 (unknown origin) | 35200035 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35200035 | 10.1021/acs.jmedchem.1c01947 | Mitogen-activated protein kinase 8 | 1 |
Data from ChEMBL 36 via Core Engine