Assay Detail
Binding
CHEMBL5146061
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human RIPK1 incubated for 40 min in presence of ATP by ADP-Glo luminescence kinase assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-interacting serine/threonine-protein kinase 1 (CHEMBL5464) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel 2,8-diazaspiro[4.5]decan-1-one derivatives as potent RIPK1 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.51 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4071864 | GSK2982772 | 2.0 | 1 | 7.48 |
| CHEMBL5179059 | — | — | 1 | 7.04 |
| CHEMBL5198841 | — | — | 1 | 6.73 |
| CHEMBL4092421 | — | — | 1 | 6.53 |
| CHEMBL5177216 | — | — | 1 | 6.21 |
| CHEMBL5187835 | — | — | 1 | 6.16 |
| CHEMBL5197133 | — | — | 1 | 6.00 |
| CHEMBL195008 | NECROSTATIN | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4071864 | GSK2982772 | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5179059 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL5198841 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL4092421 | — | IC50 | = | 298.0 | nM | 6.53 |
| CHEMBL5177216 | — | IC50 | = | 624.0 | nM | 6.21 |
| CHEMBL5187835 | — | IC50 | = | 693.0 | nM | 6.16 |
| CHEMBL5197133 | — | IC50 | = | 1007.0 | nM | 6.00 |
| CHEMBL195008 | NECROSTATIN | IC50 | = | 1139.0 | nM | 5.94 |