Compound Detail
CHEMBL5179059
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Basic Information
| ChEMBL ID | CHEMBL5179059 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YATBYSZORSKSPZ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
437.5
MW (Da)
4.11
ALogP
3
HBA
0
HBD
45.5
PSA (Ų)
0.62
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Receptor-interacting serine/threonine-protein kinase 1 CHEMBL5464 | IC50 | 7.04 | 7.04 | 92.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Receptor-interacting serine/threonine-protein kinase 1 | IC50 | = | 92.0 | nM | 7.04 | Inhibition of human RIPK1 incubated for 40 min in presence of ATP by ADP-Glo lum... | 35228069 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35228069 | 10.1016/j.bmc.2022.116686 | Receptor-interacting serine/threonine-protein kinase 1 | 3 |
| 35228069 | 10.1016/j.bmc.2022.116686 | U-937 | 2 |
Data from ChEMBL 36 via Core Engine