Assay Detail
Binding
CHEMBL5146148
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Inhibition of human topoisomerase 2 assessed as reduction in decatenation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and structure-activity relationships of a novel oxazolidinone class of bacterial type II topoisomerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.41 | 4.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5201228 | — | — | 1 | 4.84 |
| CHEMBL3317856 | GEPOTIDACIN | 3.0 | 1 | 4.26 |
| CHEMBL5195268 | — | — | 1 | 4.14 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | - |
| CHEMBL5184104 | — | — | 1 | - |
| CHEMBL5172158 | — | — | 1 | - |
| CHEMBL5182200 | — | — | 1 | - |
| CHEMBL5198597 | — | — | 1 | - |
| CHEMBL5177076 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5201228 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL3317856 | GEPOTIDACIN | IC50 | = | 55200.0 | nM | 4.26 |
| CHEMBL5195268 | — | IC50 | = | 72800.0 | nM | 4.14 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL5184104 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5172158 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5182200 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5198597 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5177076 | — | IC50 | > | 100000.0 | nM | - |