Assay Detail
Binding
CHEMBL5146299
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK2 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Lessons Learned from Past Cyclin-Dependent Kinase Drug Discovery Efforts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.49 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545083 | RGB-286638 | 1.0 | 1 | 8.52 |
| CHEMBL191003 | JNJ-7706621 | — | 1 | 8.40 |
| CHEMBL4442620 | RONICICLIB | 2.0 | 1 | 8.05 |
| CHEMBL296468 | BMS-387032 | 1.0 | 1 | 7.42 |
| CHEMBL5202522 | — | — | 1 | 6.63 |
| CHEMBL4450322 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545083 | RGB-286638 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL191003 | JNJ-7706621 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4442620 | RONICICLIB | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL296468 | BMS-387032 | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL5202522 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL4450322 | — | IC50 | = | 1300.0 | nM | 5.89 |