Assay Detail
Binding
CHEMBL5146301
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Inhibition of CDK4 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Lessons Learned from Past Cyclin-Dependent Kinase Drug Discovery Efforts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.32 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5190816 | — | — | 1 | 8.60 |
| CHEMBL3545083 | RGB-286638 | 1.0 | 1 | 8.40 |
| CHEMBL4442620 | RONICICLIB | 2.0 | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5190816 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3545083 | RGB-286638 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4442620 | RONICICLIB | IC50 | = | 11.0 | nM | 7.96 |