Assay Detail
Binding
CHEMBL5147190
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Inhibition of full length recombinant His6 tagged human RUVBL1 expressed in Escherichia coli Rosetta cells incubated for 70 mins in presence of ATP by ATPase assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of small-molecule inhibitors of RUVBL1/2 ATPase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 4.64 | 5.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5178717 | — | — | 1 | 5.11 |
| CHEMBL5199847 | — | — | 1 | 4.96 |
| CHEMBL5203235 | — | — | 1 | 4.72 |
| CHEMBL1982584 | — | — | 1 | 4.58 |
| CHEMBL5181716 | — | — | 1 | 4.51 |
| CHEMBL5207433 | — | — | 1 | 4.41 |
| CHEMBL5198140 | — | — | 1 | 4.19 |
| CHEMBL5192504 | — | — | 1 | - |
| CHEMBL5184860 | — | — | 1 | - |
| CHEMBL5177107 | — | — | 1 | - |
| CHEMBL5202618 | — | — | 1 | - |
| CHEMBL5174933 | — | — | 1 | - |
| CHEMBL5198363 | — | — | 1 | - |
| CHEMBL5196000 | — | — | 1 | - |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | - |
| CHEMBL5174379 | — | — | 1 | - |
| CHEMBL5200888 | — | — | 1 | - |
| CHEMBL5193682 | — | — | 1 | - |
| CHEMBL5189601 | — | — | 1 | - |
| CHEMBL5182007 | — | — | 1 | - |
| CHEMBL5202763 | — | — | 1 | - |
| CHEMBL5208829 | — | — | 1 | - |
| CHEMBL5199961 | — | — | 1 | - |
| CHEMBL5176698 | — | — | 1 | - |
| CHEMBL5196007 | — | — | 1 | - |
| CHEMBL5185372 | — | — | 1 | - |
| CHEMBL5187068 | — | — | 1 | - |
| CHEMBL5171082 | — | — | 1 | - |
| CHEMBL5171017 | — | — | 1 | - |
| CHEMBL5180615 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5178717 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL5199847 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5203235 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL1982584 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL5181716 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL5207433 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL5198140 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL5196000 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5176499 | — | IC50 | - | — | - | |
| CHEMBL1336 | SORAFENIB | IC50 | > | 66000.0 | nM | - |
| CHEMBL5174379 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5200888 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5193682 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5184860 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5204205 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5183749 | — | IC50 | - | — | - | |
| CHEMBL5196595 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5204197 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5176655 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5170950 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5191827 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5203675 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5184548 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5192425 | — | IC50 | - | — | - | |
| CHEMBL5208829 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5180615 | — | IC50 | - | — | - | |
| CHEMBL5171017 | — | IC50 | - | — | - | |
| CHEMBL5171082 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5187068 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5185372 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5196007 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5176698 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5199961 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5198363 | — | IC50 | - | — | - | |
| CHEMBL5202763 | — | IC50 | - | — | - | |
| CHEMBL5182007 | — | IC50 | - | — | - | |
| CHEMBL5189601 | — | IC50 | - | — | - | |
| CHEMBL5192504 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5177107 | — | IC50 | - | — | - | |
| CHEMBL5202618 | — | IC50 | - | — | - | |
| CHEMBL5174933 | — | IC50 | - | — | - |