Assay Detail
Binding
CHEMBL5147192
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Inhibition of full length recombinant His6 tagged human RUVBL1/2 expressed in Escherichia coli Rosetta cells incubated for 70 mins in presence of ATP by ATPase assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of small-molecule inhibitors of RUVBL1/2 ATPase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 4.72 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5178717 | — | — | 1 | 5.22 |
| CHEMBL5203675 | — | — | 1 | 5.21 |
| CHEMBL5196595 | — | — | 1 | 5.19 |
| CHEMBL5170950 | — | — | 1 | 5.17 |
| CHEMBL5208829 | — | — | 1 | 5.10 |
| CHEMBL5192504 | — | — | 1 | 5.10 |
| CHEMBL5184548 | — | — | 1 | 5.05 |
| CHEMBL5199847 | — | — | 1 | 5.02 |
| CHEMBL5203235 | — | — | 1 | 5.00 |
| CHEMBL5196000 | — | — | 1 | 4.96 |
| CHEMBL5204205 | — | — | 1 | 4.92 |
| CHEMBL5176655 | — | — | 1 | 4.88 |
| CHEMBL5196007 | — | — | 1 | 4.87 |
| CHEMBL5204197 | — | — | 1 | 4.80 |
| CHEMBL5199961 | — | — | 1 | 4.75 |
| CHEMBL5184860 | — | — | 1 | 4.69 |
| CHEMBL5176698 | — | — | 1 | 4.55 |
| CHEMBL5185372 | — | — | 1 | 4.51 |
| CHEMBL5187068 | — | — | 1 | 4.51 |
| CHEMBL5171082 | — | — | 1 | 4.49 |
| CHEMBL5181716 | — | — | 1 | 4.46 |
| CHEMBL5198140 | — | — | 1 | 4.44 |
| CHEMBL5193682 | — | — | 1 | 4.42 |
| CHEMBL5207433 | — | — | 1 | 4.34 |
| CHEMBL1982584 | — | — | 1 | 4.33 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 4.26 |
| CHEMBL5191827 | — | — | 1 | 4.22 |
| CHEMBL5200888 | — | — | 1 | 4.17 |
| CHEMBL5174379 | — | — | 1 | 4.11 |
| CHEMBL5171017 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5178717 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5203675 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL5196595 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL5170950 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL5208829 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5192504 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL5184548 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5199847 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL5203235 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5196000 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5204205 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5176655 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL5196007 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL5204197 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL5199961 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5184860 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL5176698 | — | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL5185372 | — | IC50 | = | 31200.0 | nM | 4.51 |
| CHEMBL5187068 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL5171082 | — | IC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL5181716 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL5198140 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL5193682 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL5207433 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL1982584 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL5191827 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL5200888 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL5174379 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL5198363 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5174933 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5202618 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5177107 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5180615 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5189601 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5182007 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5202763 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5183749 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5192425 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5176499 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL5171017 | — | IC50 | > | 66000.0 | nM | - |