Assay Detail
Functional
CHEMBL5147204
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BaF3 cells harboring EGFR L858R/T790M double mutant assessed as inhibition of cell growth
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.89 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5201543 | — | — | 1 | 7.30 |
| CHEMBL5196360 | — | — | 1 | 6.50 |
| CHEMBL5191510 | — | — | 1 | 6.31 |
| CHEMBL4443062 | — | — | 1 | 6.21 |
| CHEMBL5206902 | — | — | 1 | 6.11 |
| CHEMBL5177272 | — | — | 1 | 6.09 |
| CHEMBL5198812 | — | — | 1 | 6.00 |
| CHEMBL5182553 | — | — | 1 | 5.97 |
| CHEMBL5207108 | — | — | 1 | 5.94 |
| CHEMBL5200988 | — | — | 1 | 5.91 |
| CHEMBL5178865 | — | — | 1 | 5.90 |
| CHEMBL5197154 | — | — | 1 | 5.89 |
| CHEMBL5195912 | — | — | 1 | 5.83 |
| CHEMBL5173701 | — | — | 1 | 5.82 |
| CHEMBL5178754 | — | — | 1 | 5.81 |
| CHEMBL5187605 | — | — | 1 | 5.80 |
| CHEMBL5191674 | — | — | 1 | 5.77 |
| CHEMBL5208065 | — | — | 1 | 5.73 |
| CHEMBL5204970 | — | — | 1 | 5.70 |
| CHEMBL5200637 | — | — | 1 | 5.70 |
| CHEMBL5176460 | — | — | 1 | 5.70 |
| CHEMBL5206436 | — | — | 1 | 5.67 |
| CHEMBL5172573 | — | — | 1 | 5.63 |
| CHEMBL5204270 | — | — | 1 | 5.61 |
| CHEMBL5177306 | — | — | 1 | 5.59 |
| CHEMBL5178571 | — | — | 1 | 5.52 |
| CHEMBL5207462 | — | — | 1 | 5.46 |
| CHEMBL5202129 | — | — | 1 | 5.44 |
| CHEMBL4214567 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5201543 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5196360 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5191510 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4443062 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5206902 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL5177272 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL5198812 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5182553 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL5207108 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL5200988 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL5178865 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL5197154 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL5195912 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL5173701 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5178754 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL5187605 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5191674 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL5208065 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL5204970 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5200637 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL5176460 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL5206436 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL5172573 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL5204270 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL5177306 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL5178571 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5207462 | — | IC50 | = | 3460.0 | nM | 5.46 |
| CHEMBL5202129 | — | IC50 | = | 3660.0 | nM | 5.44 |
| CHEMBL4214567 | — | IC50 | > | 10000.0 | nM | - |