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Assay Detail

CHEMBL5147294

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of tyrosinase (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tyrosinase (CHEMBL1973)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Polyphenolic compounds: Synthesis, assessment of antimicrobial effect and enzymes inhibition against important medicinal enzymes with computational details.
İmamoğlu R, Koç E, Kısa D.
Bioorg Med Chem Lett (2022) 65 : 128722 -128722
PubMed 35395370 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 4.22 4.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL50 QUERCETIN 3.0 1 4.35
CHEMBL150 KAEMPFEROL 1.0 1 4.19
CHEMBL266564 TILIROSIDE 1 4.11

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL50 QUERCETIN IC50 = 44380.0 nM 4.35
CHEMBL150 KAEMPFEROL IC50 = 65110.0 nM 4.19
CHEMBL266564 TILIROSIDE IC50 = 78530.0 nM 4.11