Assay Detail
Functional
CHEMBL5147472
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Antiproliferative activity against mouse BaF3 cells harbouring ALK C1156Y mutant assessed as reduction in cell viability by Celltitre-Glo luminescent assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and preclinical evaluations of WX-0593, a novel ALK inhibitor targeting crizotinib-resistant mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.53 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5178402 | — | — | 1 | 7.92 |
| CHEMBL5171152 | — | — | 1 | 7.82 |
| CHEMBL5176751 | — | — | 1 | 7.77 |
| CHEMBL5095068 | IRUPLINALKIB | 2.0 | 1 | 7.68 |
| CHEMBL5179104 | — | — | 1 | 7.52 |
| CHEMBL5200942 | — | — | 1 | 7.44 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5178402 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5171152 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5176751 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5095068 | IRUPLINALKIB | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5179104 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5200942 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 284.0 | nM | 6.55 |