Assay Detail
Binding
CHEMBL5147544
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SARS-CoV-2 main protease expressed in Escherichia coli using DABCYL-KTSAVLQ1SGFRKM-E(EDANS)-NH2 peptide as substrate incubated for 30 mins by FRET based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Identification of Aloe-derived natural products as prospective lead scaffolds for SARS-CoV-2 main protease (M<sup>pro</sup>) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.79 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33778 | ANACARDIC ACID | — | 1 | 5.17 |
| CHEMBL5172191 | — | — | 1 | 4.41 |
| CHEMBL1241028 | — | — | 1 | - |
| CHEMBL5187969 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33778 | ANACARDIC ACID | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL5172191 | — | IC50 | = | 38900.0 | nM | 4.41 |
| CHEMBL1241028 | — | IC50 | = | 138000.0 | nM | - |
| CHEMBL5187969 | — | IC50 | = | 125300.0 | nM | - |