Assay Detail
Functional
CHEMBL5148332
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Antiproliferative activity against ALK-negative human HCT-116 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 2,4-diarylaminopyrimidine derivatives bearing dithiocarbamate moiety as novel ALK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.46 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5203805 | — | — | 1 | 6.01 |
| CHEMBL5176307 | — | — | 1 | 5.97 |
| CHEMBL2403108 | CERITINIB | 4.0 | 1 | 5.97 |
| CHEMBL5178030 | — | — | 1 | 5.82 |
| CHEMBL5187826 | — | — | 1 | 5.69 |
| CHEMBL5189267 | — | — | 1 | 5.66 |
| CHEMBL5175979 | — | — | 1 | 5.61 |
| CHEMBL5178392 | — | — | 1 | 5.60 |
| CHEMBL5178846 | — | — | 1 | 5.57 |
| CHEMBL5209011 | — | — | 1 | 5.56 |
| CHEMBL5179387 | — | — | 1 | 5.55 |
| CHEMBL5179262 | — | — | 1 | 5.50 |
| CHEMBL5170081 | — | — | 1 | 5.48 |
| CHEMBL5174878 | — | — | 1 | 5.47 |
| CHEMBL5203218 | — | — | 1 | 5.45 |
| CHEMBL5206284 | — | — | 1 | 5.45 |
| CHEMBL5206256 | — | — | 1 | 5.42 |
| CHEMBL5194446 | — | — | 1 | 5.41 |
| CHEMBL5185272 | — | — | 1 | 5.40 |
| CHEMBL5169860 | — | — | 1 | 5.33 |
| CHEMBL5190549 | — | — | 1 | 5.32 |
| CHEMBL5183526 | — | — | 1 | 5.31 |
| CHEMBL5184489 | — | — | 1 | 5.30 |
| CHEMBL5189035 | — | — | 1 | 5.28 |
| CHEMBL5203085 | — | — | 1 | 5.26 |
| CHEMBL5179806 | — | — | 1 | 5.26 |
| CHEMBL5174628 | — | — | 1 | 5.24 |
| CHEMBL5199005 | — | — | 1 | 5.23 |
| CHEMBL5209310 | — | — | 1 | 5.18 |
| CHEMBL5206622 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5203805 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL5176307 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL2403108 | CERITINIB | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL5178030 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL5187826 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL5189267 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL5175979 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL5178392 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL5178846 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5209011 | — | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL5179387 | — | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL5179262 | — | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL5170081 | — | IC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL5174878 | — | IC50 | = | 3360.0 | nM | 5.47 |
| CHEMBL5206284 | — | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL5203218 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL5206256 | — | IC50 | = | 3780.0 | nM | 5.42 |
| CHEMBL5194446 | — | IC50 | = | 3860.0 | nM | 5.41 |
| CHEMBL5185272 | — | IC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL5169860 | — | IC50 | = | 4670.0 | nM | 5.33 |
| CHEMBL5190549 | — | IC50 | = | 4740.0 | nM | 5.32 |
| CHEMBL5183526 | — | IC50 | = | 4890.0 | nM | 5.31 |
| CHEMBL5184489 | — | IC50 | = | 4950.0 | nM | 5.30 |
| CHEMBL5189035 | — | IC50 | = | 5280.0 | nM | 5.28 |
| CHEMBL5203085 | — | IC50 | = | 5460.0 | nM | 5.26 |
| CHEMBL5179806 | — | IC50 | = | 5530.0 | nM | 5.26 |
| CHEMBL5174628 | — | IC50 | = | 5810.0 | nM | 5.24 |
| CHEMBL5199005 | — | IC50 | = | 5930.0 | nM | 5.23 |
| CHEMBL5209310 | — | IC50 | = | 6550.0 | nM | 5.18 |
| CHEMBL5206622 | — | IC50 | = | 7030.0 | nM | 5.15 |
| CHEMBL5187645 | — | IC50 | = | 7830.0 | nM | 5.11 |
| CHEMBL5182364 | — | IC50 | = | 8150.0 | nM | 5.09 |
| CHEMBL5178177 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5195847 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5199475 | — | IC50 | > | 10000.0 | nM | - |