Assay Detail
Binding
CHEMBL5148455
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Trypanosoma brucei DHFR-TS expressed in Escherichia coli BL21 (DE3) cells using dihydrofolate as substrate in presence of NADPH by spectrophotometric analysis
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Dihydrofolate reductase-thymidylate synthase (CHEMBL5229) ↗| Type | SINGLE PROTEIN |
| Organism | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) |
Publication
Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.45 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL426 | — | — | 1 | 8.00 |
| CHEMBL5199171 | — | — | 1 | 6.64 |
| CHEMBL1232702 | — | — | 1 | 6.57 |
| CHEMBL5201183 | — | — | 1 | 6.47 |
| CHEMBL5171609 | — | — | 1 | 6.37 |
| CHEMBL26006 | — | — | 1 | 6.35 |
| CHEMBL5200612 | — | — | 1 | 6.23 |
| CHEMBL5183748 | — | — | 1 | 6.21 |
| CHEMBL5180552 | — | — | 1 | 6.21 |
| CHEMBL5182291 | — | — | 1 | 6.01 |
| CHEMBL5204239 | — | — | 1 | 6.01 |
| CHEMBL5175012 | — | — | 1 | 6.00 |
| CHEMBL5193564 | — | — | 1 | 5.93 |
| CHEMBL5184936 | — | — | 1 | 5.92 |
| CHEMBL2178602 | — | — | 1 | 5.90 |
| CHEMBL2178604 | — | — | 1 | 5.86 |
| CHEMBL5197107 | — | — | 1 | 5.84 |
| CHEMBL5182125 | — | — | 1 | 5.62 |
| CHEMBL2178600 | — | — | 1 | 5.59 |
| CHEMBL2178599 | — | — | 1 | 5.54 |
| CHEMBL5205559 | — | — | 1 | 5.52 |
| CHEMBL5206994 | — | — | 1 | 5.05 |
| CHEMBL5188304 | — | — | 1 | 4.75 |
| CHEMBL5170968 | — | — | 1 | 4.71 |
| CHEMBL1232399 | — | — | 1 | 4.69 |
| CHEMBL5184646 | — | — | 1 | 4.46 |
| CHEMBL5193762 | — | — | 1 | 4.36 |
| CHEMBL5173732 | — | — | 1 | 4.35 |
| CHEMBL5205037 | — | — | 1 | 4.00 |
| CHEMBL5180685 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL426 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5199171 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1232702 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5201183 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5171609 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL26006 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5200612 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL5183748 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL5180552 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL5182291 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL5204239 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL5175012 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL5193564 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL5184936 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2178602 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL2178604 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL5197107 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL5182125 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2178600 | — | IC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL2178599 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL5205559 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5206994 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5188304 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5170968 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL1232399 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL5184646 | — | IC50 | = | 34900.0 | nM | 4.46 |
| CHEMBL5193762 | — | IC50 | = | 44100.0 | nM | 4.36 |
| CHEMBL5173732 | — | IC50 | = | 44300.0 | nM | 4.35 |
| CHEMBL5205037 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL5180685 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL5201599 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL5208403 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL5175397 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL5198855 | — | IC50 | = | 100000.0 | nM | 4.00 |