Assay Detail
Functional
CHEMBL5148463
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei Lister 427 assessed as parasite growth inhibition incubated for 72 hrs by resazurin dye based analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.53 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.72 |
| CHEMBL5201183 | — | — | 1 | 6.18 |
| CHEMBL5184646 | — | — | 1 | 5.89 |
| CHEMBL5193762 | — | — | 1 | 5.34 |
| CHEMBL5188304 | — | — | 1 | - |
| CHEMBL5200612 | — | — | 1 | - |
| CHEMBL5199171 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5201183 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL5184646 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5193762 | — | EC50 | = | 4530.0 | nM | 5.34 |
| CHEMBL5188304 | — | EC50 | - | — | - | |
| CHEMBL5200612 | — | EC50 | - | — | - | |
| CHEMBL5199171 | — | EC50 | - | — | - |