Assay Detail
Binding
CHEMBL5148483
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at LBD fused human FXR in HEK293 cells incubated for 30 min by envision plate reader method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of BMS-986339, a Pharmacologically Differentiated Farnesoid X Receptor Agonist for the Treatment of Nonalcoholic Steatohepatitis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.92 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5182534 | — | — | 1 | 7.38 |
| CHEMBL4862974 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5182534 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4862974 | — | EC50 | = | 351.0 | nM | 6.46 |