Assay Detail
ADMET
CHEMBL5148495
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Inhibition of recombinant CYP2C19 (unknown origin) using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hrs by fluorescence method
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of BMS-986339, a Pharmacologically Differentiated Farnesoid X Receptor Agonist for the Treatment of Nonalcoholic Steatohepatitis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.17 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5184419 | — | — | 1 | 6.52 |
| CHEMBL5190243 | — | — | 1 | 6.00 |
| CHEMBL5180682 | — | — | 1 | 5.70 |
| CHEMBL5177647 | — | — | 1 | 5.22 |
| CHEMBL5189617 | — | — | 1 | 5.16 |
| CHEMBL5182534 | — | — | 1 | 5.16 |
| CHEMBL5204648 | — | — | 1 | 5.10 |
| CHEMBL5182204 | — | — | 1 | 5.10 |
| CHEMBL5173549 | — | — | 1 | 5.05 |
| CHEMBL5202191 | — | — | 1 | 5.05 |
| CHEMBL5170740 | — | — | 1 | 5.05 |
| CHEMBL5178315 | — | — | 1 | 5.00 |
| CHEMBL5205416 | — | — | 1 | 4.89 |
| CHEMBL5194619 | — | — | 1 | 4.77 |
| CHEMBL5199184 | — | — | 1 | 4.70 |
| CHEMBL5172239 | — | — | 1 | 4.70 |
| CHEMBL5189418 | — | — | 1 | 4.70 |
| CHEMBL5208567 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5184419 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5190243 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5180682 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5177647 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5189617 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL5182534 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL5204648 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5182204 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5173549 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5202191 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5170740 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5178315 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5205416 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5194619 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL5199184 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5172239 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5189418 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5208567 | — | IC50 | - | — | - |