Assay Detail
Binding
CHEMBL5149640
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MSK2 (unknown origin) FAM-PSKPAATRKRRWSAPESR-NH2 as substrate preincubated for 1 hr followed by activation with ERK2 and substrate addition measured after 2 hrs by microfluidic chip based electrophoresis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.38 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5184056 | — | — | 1 | 7.70 |
| CHEMBL5190298 | — | — | 1 | 7.10 |
| CHEMBL5187801 | — | — | 1 | 6.10 |
| CHEMBL5183977 | — | — | 1 | 5.50 |
| CHEMBL5198790 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5184056 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL5190298 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL5187801 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL5183977 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL5198790 | — | IC50 | = | 3162.28 | nM | 5.50 |