Assay Detail
Binding
CHEMBL5149786
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Inhibition of human recombinant renin using sheep recombinant angiotensinogen substrate incubated for 1 hr by EIA
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.21 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5181888 | — | — | 1 | 6.11 |
| CHEMBL5199179 | — | — | 1 | 4.92 |
| CHEMBL5205574 | — | — | 1 | 4.60 |
| CHEMBL5185263 | — | — | 1 | - |
| CHEMBL5186347 | — | — | 1 | - |
| CHEMBL5177567 | — | — | 1 | - |
| CHEMBL5187637 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5181888 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL5199179 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5205574 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL5185263 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5186347 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5177567 | — | IC50 | - | — | - | |
| CHEMBL5187637 | — | IC50 | - | — | - |