Compound Detail
CHEMBL5199179
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Basic Information
| ChEMBL ID | CHEMBL5199179 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YXMKCWJEXYMJQU-MRXNPFEDSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
362.5
MW (Da)
2.21
ALogP
5
HBA
1
HBD
60.0
PSA (Ų)
0.65
QED
0
Ro5 Violations
10
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Renin CHEMBL286 | IC50 | 4.92 | 4.92 | 12000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Renin | IC50 | = | 12000.0 | nM | 4.92 | Inhibition of human recombinant renin using sheep recombinant angiotensinogen su... | 35978678 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35978678 | 10.1021/acsmedchemlett.2c00280 | Renin | 2 |
Data from ChEMBL 36 via Core Engine