Assay Detail
Functional
CHEMBL5149864
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Agonist activity at human OX2R expressed in CHO cells incubated for 2 hrs by IP-one detection reagent based fluorescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel 3-Aminopyrrolidine and Piperidine Macrocyclic Orexin Receptor Agonists for Treating Sleep Disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 10.15 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5196538 | — | — | 1 | 10.40 |
| CHEMBL5194793 | — | — | 1 | 10.30 |
| CHEMBL5177846 | — | — | 1 | 10.15 |
| CHEMBL5195414 | — | — | 1 | 10.05 |
| CHEMBL5190821 | — | — | 1 | 10.00 |
| CHEMBL5206338 | — | — | 1 | 10.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5196538 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL5194793 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL5177846 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL5195414 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL5190821 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL5206338 | — | IC50 | = | 0.1 | nM | 10.00 |